Primary disorders of lipoprotein metabolism in childhood.

FoUR major classes of lipid are found in human serum: cholesterol and its esters, triglyceride, phospholipids and non-esterified fatty acids. They exist in aqueous solution because they are combined with protein to form lipoprotein complexes. The non-esterified fatty acids are bound to albumin, and the other lipids are associated with certain serum globulins. The nomenclature of the lipoproteins derives from the methods used for their separation. The simplest method is paper electrophoresis (Salt & Wolff, 1957; Fredrickson, Levy & Lees, 1967a) and using this technique four